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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Among authors: hughes mm. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.
Hooftman A, Angiari S, Hester S, Corcoran SE, Runtsch MC, Ling C, Ruzek MC, Slivka PF, McGettrick AF, Banahan K, Hughes MM, Irvine AD, Fischer R, O'Neill LAJ. Hooftman A, et al. Among authors: hughes mm. Cell Metab. 2020 Sep 1;32(3):468-478.e7. doi: 10.1016/j.cmet.2020.07.016. Epub 2020 Aug 12. Cell Metab. 2020. PMID: 32791101 Free PMC article.
Metabolic regulation of NLRP3.
Hughes MM, O'Neill LAJ. Hughes MM, et al. Immunol Rev. 2018 Jan;281(1):88-98. doi: 10.1111/imr.12608. Immunol Rev. 2018. PMID: 29247992 Review.
Caspase-11 promotes allergic airway inflammation.
Zasłona Z, Flis E, Wilk MM, Carroll RG, Palsson-McDermott EM, Hughes MM, Diskin C, Banahan K, Ryan DG, Hooftman A, Misiak A, Kearney J, Lochnit G, Bertrams W, Greulich T, Schmeck B, McElvaney OJ, Mills KHG, Lavelle EC, Wygrecka M, Creagh EM, O'Neill LAJ. Zasłona Z, et al. Among authors: hughes mm. Nat Commun. 2020 Feb 26;11(1):1055. doi: 10.1038/s41467-020-14945-2. Nat Commun. 2020. PMID: 32103022 Free PMC article.
Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
Hughes MM, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch MC, McGettrick AF, Sutton CE, Diskin C, Rooke M, Takahashi S, Sundararaj S, Casarotto MG, Dahlstrom JE, Palsson-McDermott EM, Corr SC, Mills KHG, Preston RJS, Neamati N, Xie Y, Baell JB, Board PG, O'Neill LAJ. Hughes MM, et al. Cell Rep. 2019 Oct 1;29(1):151-161.e5. doi: 10.1016/j.celrep.2019.08.072. Cell Rep. 2019. PMID: 31577945 Free article.
A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.
Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J. Ní Cheallaigh C, et al. Among authors: hughes mm. Immunity. 2016 Feb 16;44(2):368-79. doi: 10.1016/j.immuni.2016.01.019. Immunity. 2016. PMID: 26885859 Free PMC article.